Combating Susceptibility to Drug Resistance

Combating and overcoming drug resistance in cancer

While the majority of patients with cancer treated with chemotherapy initially respond to treatment, a sub-group of patients either do not respond or eventually stop responding to the therapy in a phenomenon known as tumor cell resistance. Evidence of many different mechanisms of resistance have been reported in the literature, and it remains a great challenge to delineate the pathways involved...

In silico Studies on Selected Drug Targets for Combating Drug Resistance in Plasmodium falcifarum

With drug resistance becoming widespread in Plasmodium falciparum infections, the development of the alternative drugs is the desired strategy for prevention and cure of malaria. Three drug targets were selected to screen promising drug molecules from the GSK library of 13469 molecules. Using an in silico structurebased drug designing approach, the differences in binding energies of the substra...

Drug Resistance

عفونت و تهاجم ارگانیسم های انگلی به بدن، عامل اصلی بیماری و مرگ انسانها از آغاز بشریت بوده است . در حقیقت بسیاری از اشکال حیات بدون غلبه بر ارگانیسم های زنده دیگر، قادر به ادامه زندگی نخواهند بود. انسانها معمولا مستعد تهاجم ارگانیسم های کوچکتری مانند کرمها، آمیب ها، قارچها، باکتریها و ویروسها هستند. این عوامل مکان خاصی را در بدن انتخاب کرده، مواد ضروری لازم برای حیات و تکثیر خود را دریافت نموده...

Combating Antimicrobial Resistance: Policy Recommendations to Save Lives

Antimicrobial resistance is recognized as one of the greatest threats to human health worldwide [1]. Drugresistant infections take a staggering toll in the United States (US) and across the globe. Just one organism, methicillin-resistant Staphylococcus aureus (MRSA), kills more Americans every year ( 19,000) than emphysema, HIV/AIDS, Parkinson’s disease, and homicide combined [2]. Almost 2 mill...

Bacterial SOS May Be the Key to Combating Antibiotic Resistance